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Synthesis of isocoumarins via thallation-olefination of benzoic acids

…, S Varaprath, HH Lau, CA Fellows

文献索引:Larock, R. C.; Varaprath, S.; Lau, H. H.; Fellows, C. A. Journal of the American Chemical Society, 1984 , vol. 106, # 18 p. 5274 - 5284

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被引用次数: 122

摘要

Abstract: Benzoic acid and substituted benzoic acids are readily thallated by thallium (II1) trifluoroacetate and subsequently reacted with palladium chloride and simple olefins, allylic halides, vinyl halides, or vinyl esters to give isocoumarins. The organic halide reactions are catalytic in palladium. 1, 2-and 1, 3-dienes also react catalytically to afford 4-alkylidene-and 3-vinyl-3, 4-dihydroisocoumarins, respectively. Vinylcyclopropanes also afford 3-vinyl-3, 4 ...

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