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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and evaluation of nitro 5-deazaflavin-pyrrolecarboxamide (s) hybrid molecules as novel DNA targeted bioreductive antitumor agents

Y Kanaoka, Y Ikeuchi, T Kawamoto, K Bessho…

文献索引：Kanaoka, Yoshitomo; Ikeuchi, Yoshihiro; Kawamoto, Tetsuji; Bessho, Kiyoshi; Akimoto, Naoshige; Mikata, Yuji; Nishida, Mamiko; Yano, Shigenobu; Sasaki, Takuma; Yoneda, Fumio Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 3 p. 301 - 314

全文：HTML全文

被引用次数: 17

摘要

A series of 6-nitro-5-deazaflavins bearing at N (3) or N (10) position the pyrrolecarboxamide (s) group as DNA minor groove binder has been synthesized. These hybrid molecules show similar redox properties to those of 6-nitro-5-deazaflavins with no pyrrolecarboxamide (s) group, suggesting that they generate stable one-and two-electron reduction product (s). Electrolytic reductions of the hybrid molecules were carried out at a controlled potential ...

1-甲基-4-硝基-2-(三氯乙酰)-1H-吡咯结构式

1-甲基-4-硝基-2-(三氯...

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N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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2-氟-6-硝基苯甲醛结构式

2-氟-6-硝基苯甲醛

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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6-氯-3-甲基尿嘧啶结构式

6-氯-3-甲基尿嘧啶

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N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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邻氟苯甲醛结构式

邻氟苯甲醛

2,4(1H,3H)-Pyrimidinedione,6-(butylamino)结构式

2,4(1H,3H)-Pyri...

~88%

Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 10-butyl结构式

Pyrimido[4,5-b]...

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1-甲基-4-硝基-2-(三氯乙酰)-1H-吡咯结构式

1-甲基-4-硝基-2-(三氯...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-(4-amino-1-methylpyrrole-2-carboxamido)pyrrole-2-carboxamide结构式

N-butyl-1-methy...

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N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-nitropyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-[1-methyl-4-(1-methyl-4-nitropyrrole-2-carboxamido)pyrrole-2-carboxamido]pyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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2-氟-6-硝基苯甲醛结构式

2-氟-6-硝基苯甲醛

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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6-氯-3-甲基尿嘧啶结构式

6-氯-3-甲基尿嘧啶

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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1-甲基-4-硝基-2-(三氯乙酰)-1H-吡咯结构式

1-甲基-4-硝基-2-(三氯...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-(4-amino-1-methylpyrrole-2-carboxamido)pyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-nitropyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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N-butyl-1-methyl-4-[1-methyl-4-(1-methyl-4-nitropyrrole-2-carboxamido)pyrrole-2-carboxamido]pyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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2-氟-6-硝基苯甲醛结构式

2-氟-6-硝基苯甲醛

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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2,4(1H,3H)-Pyrimidinedione,6-(butylamino)结构式

2,4(1H,3H)-Pyri...

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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未登录结构式

~%

N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-[[5-(butyl...

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1-甲基-4-硝基-2-(三氯乙酰)-1H-吡咯结构式

1-甲基-4-硝基-2-(三氯...

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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N-butyl-1-methyl-4-(4-amino-1-methylpyrrole-2-carboxamido)pyrrole-2-carboxamide结构式

N-butyl-1-methy...

2,5-dioxopyrrolidin-1-yl 2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3(2H,4H,10H)-yl)acetate结构式

2,5-dioxopyrrol...

~54%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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未登录结构式

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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N-butyl-1-methyl-4-nitropyrrole-2-carboxamide结构式

N-butyl-1-methy...

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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未登录结构式

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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2-氟-6-硝基苯甲醛结构式

2-氟-6-硝基苯甲醛

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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2,4(1H,3H)-Pyrimidinedione,6-(butylamino)结构式

2,4(1H,3H)-Pyri...

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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未登录结构式

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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未登录结构式

~%

N-[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]-4-[[2-(10-butyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-3-yl)acetyl]amino]-1-methylpyrrole-2-carboxamide结构式

N-[5-(butylcarb...

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