Synthesis of methylene-bridged polycyclic aromatic hydrocarbons: an efficient, double Friedel-Crafts cyclization approach to 11H-benz [bc] aceanthrylene

T Gimisis, JW Kampf, M Koreeda

文献索引：Gimisis, Thanasis; Kampf, Jeff W.; Koreeda, Masato Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5858 - 5861

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被引用次数: 5

摘要

Methylene-bridged polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants1 that are often found in even higher concentrations than the wellrecognized PAHs with bay-region methyl groups. 2 A number of PAHs with a methylene bridge traversing the bay region: see, eg, l5, l6-dihydro-l, ll-methanocyclopenta [alphenanthren-17-one (2): have been shown to exhibit potent tumorigenic activity. This somewhat unexpected observation ...