A glyceride derivative of L-Dopa, 1, 3-dihexadecanoyl-2-[(S)-2-amino-3-(3, 4- dihydroxyphenyl) propanoyl] propane-1, 2, 3-triol (l), was synthesized and tested as an orally administrable prodrug endowed with lymphotropic properties. In the oxotremorine and reserpine tests, 1 exhibited an anti-Parkinsonian activity of longer duration than L-Dopa. The time course of concentration of 1 in the intestinal lymph of rat was determined and ...
