Hydroxylated aromatic inhibitors of HIV-1 integrase

…, AM Carothers, D Grunberger, J Driscoll…

文献索引：Burke Jr.; Fesen; Mazumder; Wang; Carothers; Grunberger; Driscoll; Kohn; Pommier Journal of Medicinal Chemistry, 1995 , vol. 38, # 21 p. 4171 - 4178

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被引用次数: 208

摘要

Efficient replication of HIV-1 requires integration of a DNA copy of the viral genome into a chromosome of the host cell. Integration is catalyzed by the viral integrase, and we have previously reported that phenolic moieties in compounds such as flavones, caffeic acid phenethyl ester (CAPE, 2), and curcumin confer inhibitory activity against HIV-1 integrase. We now extend these findings by performing a comprehensive structure-activity ...