Regioselective covalent modification of hemoglobin in search of antisickling agents

S Park, BL Hayes, F Marankan…

文献索引：Yamasaki, Tetsuo; Kawaminami, Eiji; Uchimura, Fumi; Okamoto, Yoshinari; Okawara, Tadashi; Furukawa, Mitsuru Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 825 - 829

全文：HTML全文

被引用次数: 26

摘要

... Journal of Medicinal Chemistry. ... J. Med. Chem. ... For example, amine isothiocyanate 7 and acid isothiocyanate 9 showed a clear preference for the β-subunit. But heterocyclic isothiocyanates 12 and 13 had about a 10−20% selectivity for the α-subunit relative to the β-subunit. ...