Enzymes in organic synthesis. 39. Preparations of chiral cyclic acid-esters and bicyclic lactones via stereoselective pig liver esterase catalyzed hydrolyses of cyclic …
G Sabbioni, JB Jones
文献索引：Sabbioni, Gabriele; Jones, J. Bryan Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4565 - 4570
Results The meso diester substrates 1-7, and the racemic lactones (*)-15-19 required as ee reference standards, were prepared by unexceptional methods. The viability of 1-7 as PLE substrates was established by measuring their rates of hydrolysis relative to that of ethyl butyrate. The observed rates for each were in the range of 4-7 (ethyl butanoate= loo), well in excess of the 0.02% of ethyl butanoate minimum needed to assure good preparative- ...
