Synthesis

Palladium-Catalyzed Cross-Coupling Reaction of Aryltriethoxysilanes with Aryl Bromides under Basic Aqueous Conditions

M Murata, R Shimazaki, S Watanabe, Y Masuda

文献索引：Murata; Shimazaki; Watanabe; Masuda Synthesis, 2001 , # 15 p. 2231 - 2233

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被引用次数: 25

摘要

A series of reactions of phenyltriethoxysilane 1a (0.6 mmol) with 2a (0.5 mmol) were performed under several conditions for optimization studies. This coupling work was achieved with the aid of an aqueous base analogous to the Suzuki-Miyaura reaction. [1] In the presence of PdCl 2 (MeCN) 2 (0.015 mmol) and an aqueous solution of hydroxide ion (1.5 mmol) as an accelerating additive, the reaction in dioxane (2 mL) gave the desired biaryl 3 in 78-94% yields along ...