Tetrahedron letters

Microwave-enhanced rhodium-catalyzed conjugate-addition of aryl boronic acids to unprotected maleimides

PS Iyer, MM O'Malley, MC Lucas

文献索引：Iyer, Pravin S.; O'Malley, Meaghan M.; Lucas, Matthew C. Tetrahedron Letters, 2007 , vol. 48, # 25 p. 4413 - 4418

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被引用次数: 13

摘要

Various boronic acids were treated with a rhodium (I) catalyst enabling their 1, 4-conjugate addition to unprotected maleimide. The scope of the reaction was explored to include both electron-rich and electron poor boronic acids. These reactions were also performed in the microwave resulting in reduced reaction times and improved efficiencies. Additionally, substrates that were recalcitrant under conventional conditions were successfully reacted ...