Synlett

A multi-task palladium catalyst involved in Heck-Reduction-Cyclization sequences for the preparation of 4-benzyl-1, 2-dihydroisoquinolin-3-ones: An unusual …

J Laudien, E Fouquet, C Zakri, FX Felpin

文献索引：Laudien, Julia; Fouquet, Eric; Zakri, Cecile; Felpin, Francois-Xavier Synlett, 2010 , # 10 p. 1539 - 1543

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被引用次数: 6

摘要

Abstract A mixed homogeneous-heterogeneous catalysis that exploits a multi-task palladium catalyst has been developed for one-pot sequential Heck-reduction-cyclization (HRC) reactions leading to novel 4-benzyl-1, 2-dihydroisoquinolin-3-ones. The HRC sequence requires mild conditions and allows the separation of the palladium residues under the form of an in situ generated Pd (0)/C catalyst by simple filtration. The homemade and recovered ...