Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cyclo Sal-FdUMP)—A New Prodrug Approach for FdUMP

…, C Meier, E De Clercq, J Balzarini

文献索引：Lorey, Martina; Meier, Chris; De Clercq, Eric; Balzarini, Jan Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1307 - 1310

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被引用次数: 15

摘要

Abstract The synthesis of cyclo Sal-FdUMP 3 ad as a new prodrug approach for FdU 1 is described. Phosphotriesters 3 release the FdUMP 2 selectively by a controlled, chemically induced tandem reaction in hydrolysis studies. The biological activity (IC50) of cyclo Sal- phosphotriesters 3 was evaluated in FM3A/O cells and FM3A/TK− cells.