Synthesis and cytokine modulation properties of pyrrolo [2, 3-d]-4-pyrimidone nucleosides

G Wang, RC Tam, E Gunic, J Du, J Bard…

文献索引：Wang, Guangyi; Tam, Robert C.; Gunic, Esmir; Du, Jinfa; Bard, Josie; Pai, Bharati Journal of Medicinal Chemistry, 2000 , vol. 43, # 13 p. 2566 - 2574

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被引用次数: 21

摘要

A series of pyrrolo [2, 3-d] pyrimidone nucleosides were synthesized and evaluated for their ability to enhance Type 2 cytokines and to suppress Type 1 cytokines in human T cells activated in vitro. Compounds 16b, 16c, 16d, 18c, and 19b induced substantial enhancement of IL-4 (a Type 2 cytokine) levels while three compounds (16b, 16c, and 16f) showed significant suppression of IFNγ (a Type 1 cytokine) levels. The results revealed a ...