Synthesis and Pharmacological Evaluation of Some 3??(4??Methylphenyl)??2??substituted amino??3H??quinazolin??4??ones as Analgesic and Anti??inflammatory Agents
Abstract A variety of 3-(4-methyl phenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin- 4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one was synthesized from 4-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. While ...
