Abstract Due to the continued interest in new bifunctional chelating agents (BFCA), we focused on the development of a convenient synthesis of 1, 4, 7, 10-tetraazacyclododecane- 1, 4, 7-tris (acetic acid)-10-butyrate mono (N-hydroxysuccinimidyl ester). It consists in the macrocycle DO3A derivatized with an aliphatic linker containing an active ester that requires selective and mild conditions to react with the targeting biomolecule. It is important to ...
