Stereocontrolled total synthesis of (5 Z, 8 Z 11 Z, 13 E)(15 S)-15-hydroxyeicosa-5, 8, 11, 13-tetraenoic acid (15 S-HETE) and analogues

KC Nicolaou, T Ladduwahetty…

文献索引：Nicolaou, K. C.; Ladduwahetty, Tamara; Elisseou, E. Michael Journal of the Chemical Society, Chemical Communications, 1985 ,  # 22  p. 1580 - 1581

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被引用次数: 12

摘要

Published on 01 January 1985. Downloaded by google on 07/05/2016 20:46:06. ... View Article Online / Journal Homepage / Table of Contents for this issue ... I I OR (15) R SiBu'Me R = H (1) 'k (16) ... 6SiBu' Me, (13) Scheme 1. Reagents and conditions (THF = tetrahydofuran; DMF = dimethylformamide): a, ButMezSiCI (1.1 equiv.), imidazole (1.1 equiv.), DMF, 0 + 25 "C, 95%; b, EtMgBr (1.1 equiv., 0.5 M in THF), THF, 0 + 50 "C, then CuBr (0.04 equiv.), 0 + 25 ...