Abstract: Seventeen eudistomins have been isolated from the Caribbean colonial tunicate Eudistoma olivaceum. Twelve are@-carbolines-four of them (eudistomins D, J, N, and 0) unsubstituted at CI, three (A, B, and M) with pyrrol-2-yl substituents at CI, and five (G, H, I, P, and Q) with I-pyrrolin-2-yl substituents at CI; five (eudistomins C, E, F, K, and L) are 1, 2, 3, 4- tetrahydro-@-carbolines with an oxathiazepine ring fused at Cl and N-2. Syntheses are ...
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