Computer-aided design, synthesis and biological assay of p-methylsulfonamido phenylethylamine analogues

H Liu, M Ji, H Jiang, L Liu, W Hua, K Chen…

文献索引：Liu, Hong; Ji, Min; Jiang, Hualiang; Liu, Ligang; Hua, Weiyi; Chen, Kaixian; Ji, Ruyun Bioorganic and Medicinal Chemistry Letters, 2000 ,  vol. 10,  # 19  p. 2153 - 2157

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被引用次数: 13

摘要

Class III antiarrhythmic agents selectively delay the effective refractory period (ERP) and increase the transmembrance action potential duration (APD). Based on our previous studies, a set of 17 methylsulfonamido phenylethylamine analogues were investigated by 3D-QSAR techniques of CoMFA and CoMSIA. The 3D-QSAR models proved a good predictive ability, and could describe the steric, electrostatic and hydrophobic ...