One??Pot Synthesis of 6??Hydroxyisochromans: The Example of Demethyl??oxa??coclaurine

…, A Bianco, C Marra, C Cavarischia

文献索引：Guiso, Marcella; Bianco, Armandodoriano; Marra, Carolina; Cavarischia, Claudia European Journal of Organic Chemistry, 2003 , # 17 p. 3407 - 3411

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被引用次数: 21

摘要

Abstract Using a modified oxa-Pictet Spengler reaction that we recently described, we synthesized 6-hydroxy-isochromans and their 7-hydroxy derivatives. The successful one step synthesis did not require protecting groups and provided high yields. The obtainment of 1-(4′-hydroxybenzyl)-6, 7-dihydroxyisochroman (1) indicates that this protocol can be used to synthesize oxygenated analogues of benzyl-tetrahydroisoquinoline alkaloids, such as ...