Oligo (2′-O-methylribonucleotides) and their derivatives: IV. Conjugates of oligo (2′-O-methylribonucleotides) with minor groove binders and intercalators: …

…, VA Ryabinin, L Perrouault, C Giovannangeli…

文献索引：Novopashina; Sinyakov; Ryabinin; Perrouault; Giovannangeli; Venyaminova; Boutorine Russian Journal of Bioorganic Chemistry, 2013 , vol. 39, # 2 p. 138 - 152 Bioorg. Khim., 2013 , vol. 39, # 2 p. 159 - 174,16

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摘要

Abstract Triplex forming 3′-protected pyrimidine oligo (2′-O-methylribonucleotides) containing minor groove binders (MGB) and triplex specific intercalator, benzoindoloquinoline (BIQ), at the 5′-terminus were synthesized. The resulting conjugates formed stable complexes with a target dsDNA due to the simultaneous binding to the minor and major grooves and BIQ intercalation. The dissociation constants and the thermal ...