Concise Stereoselective Synthesis of (2S,4R)-4-Hydroxyproline from (S)-0-Benzylglycidol by a Novel Cyclization ... Seiichi Takano," Yoshiharu Iwabuchi, and Kunio Ogasawara Pharmaceutical Institute, Tohoku University, Aoba yama, Sendai 980, Japan ... An efficient stereoselective route to (2S,4R)-4-hydroxyproIine from (S)-0-benzylglycidol has been established via a novel iodine-mediated cyclization of the N-benzoyl-y,G-unsaturated amide.
