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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Synthesis of trichostatin A, a potent differentiation inducer of Friend leukemic cells, and its antipode

K Mori, K Koseki

文献索引：Mori, Kenji; Koseki, Koshi Tetrahedron, 1988 , vol. 44, # 19 p. 6013 - 6020

全文：HTML全文

被引用次数: 110

摘要

This document does not have an outline. ... JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. ... Author links open the overlay panel. Numbers correspond to the affiliation list which can be exposed by using the show more link. ... Both the enantiomers of trichostatic acid (1, 98% ee) and trichostatin A (2, 93% ee) were synthesized employing methyl (R)- or (S)-3-hydroxy-2-methyl-propanoate as a starting material.

(R)-曲古抑菌酸结构式

(R)-曲古抑菌酸

~%

(-)-曲古柳菌素A结构式

(-)-曲古柳菌素A

(2S)-3-(4-(dimethylamino)phenyl)-3-((2-methoxypropan-2-yl)oxy)-2-methylpropanal结构式

(2S)-3-(4-(dime...

~%

(-)-曲古柳菌素A结构式

(-)-曲古柳菌素A

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-2-(S)-methyl-1-propanol结构式

3-t-butyldimeth...

~%

(2S)-3-(4-(dimethylamino)phenyl)-3-((2-methoxypropan-2-yl)oxy)-2-methylpropanal结构式

(2S)-3-(4-(dime...

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-1-(2-methoxypropyloxy)-2-(S)-methylpropane结构式

3-t-butyldimeth...

~%

(2S)-3-(4-(dimethylamino)phenyl)-3-((2-methoxypropan-2-yl)oxy)-2-methylpropanal结构式

(2S)-3-(4-(dime...

(2R)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-methyl-1-propanol结构式

(2R)-3-{[tert-b...

~%

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-1-(2-methoxypropyloxy)-2-(S)-methylpropane结构式

3-t-butyldimeth...

(2S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropanal结构式

(2S)-3-[[(1,1-d...

~%

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-1-(2-methoxypropyloxy)-2-(S)-methylpropane结构式

3-t-butyldimeth...

(2R)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-methyl-1-propanol结构式

(2R)-3-{[tert-b...

~%

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-2-(S)-methyl-1-propanol结构式

3-t-butyldimeth...

methyl 4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-(2-methoxypropyloxy)-2,4-heptadienoate结构式

methyl 4,6-(R)-...

~81%

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol结构式

3-(4'-N,N-dimet...

~%

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol结构式

2,4-(R)-dimethy...

~%

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

(4R,5R,E)-5-(4-(dimethylamino)phenyl)-5-((2-methoxypropan-2-yl)oxy)-2,4-dimethylpent-2-enal结构式

(4R,5R,E)-5-(4-...

~%

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

ethyl 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-pentenoate结构式

ethyl 2,4-(R)-d...

~%

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

(2S)-3-(4-(dimethylamino)phenyl)-3-((2-methoxypropan-2-yl)oxy)-2-methylpropanal结构式

(2S)-3-(4-(dime...

~%

O-(2-methoxypropyl)-(S)-trichostatin A结构式

O-(2-methoxypro...

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-2-(S)-methyl-1-propanol结构式

3-t-butyldimeth...

~%

O-(2-methoxypropyl)-(S)-trichostatin A结构式

O-(2-methoxypro...

3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-1-(2-methoxypropyloxy)-2-(S)-methylpropane结构式

3-t-butyldimeth...

~%

O-(2-methoxypropyl)-(S)-trichostatin A结构式

O-(2-methoxypro...

3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol结构式

3-(4'-N,N-dimet...

~%

methyl 4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-(2-methoxypropyloxy)-2,4-heptadienoate结构式

methyl 4,6-(R)-...

2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol结构式

2,4-(R)-dimethy...

~%

methyl 4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-(2-methoxypropyloxy)-2,4-heptadienoate结构式

methyl 4,6-(R)-...

ethyl 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-pentenoate结构式

ethyl 2,4-(R)-d...

~%

methyl 4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-(2-methoxypropyloxy)-2,4-heptadienoate结构式

methyl 4,6-(R)-...

4,6-(R)-dimethyl-7-(4'-N,N-dimethylaminophenyl)-7-hydroxy-2,4-heptadienoic acid结构式

4,6-(R)-dimethy...

~37%

(R)-曲古抑菌酸结构式

(R)-曲古抑菌酸

3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol结构式

3-(4'-N,N-dimet...

~%

(4R,5R,E)-5-(4-(dimethylamino)phenyl)-5-((2-methoxypropan-2-yl)oxy)-2,4-dimethylpent-2-enal结构式

(4R,5R,E)-5-(4-...

ethyl 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-pentenoate结构式

ethyl 2,4-(R)-d...

~%

(4R,5R,E)-5-(4-(dimethylamino)phenyl)-5-((2-methoxypropan-2-yl)oxy)-2,4-dimethylpent-2-enal结构式

(4R,5R,E)-5-(4-...

2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol结构式

2,4-(R)-dimethy...

~%

(4R,5R,E)-5-(4-(dimethylamino)phenyl)-5-((2-methoxypropan-2-yl)oxy)-2,4-dimethylpent-2-enal结构式

(4R,5R,E)-5-(4-...

ethyl 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-pentenoate结构式

ethyl 2,4-(R)-d...

~90%

2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol结构式

2,4-(R)-dimethy...

3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol结构式

3-(4'-N,N-dimet...

~%

2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol结构式

2,4-(R)-dimethy...

3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol结构式

3-(4'-N,N-dimet...

~%

ethyl 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-pentenoate结构式

ethyl 2,4-(R)-d...