Steroids

Synthesis of [11 C] PBR06 and [18 F] PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)

M Wang, M Gao, KD Miller, QH Zheng

文献索引：Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Zheng, Qi-Huang Steroids, 2011 , vol. 76, # 12 p. 1331 - 1340

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被引用次数: 33

摘要

The translocator protein 18kDa (TSPO) is an attractive target for molecular imaging of neuroinflammation and tumor progression.[18F] PBR06, a fluorine-18 labeled form of PBR06, is a promising PET TSPO radioligand originally developed at NIMH.[11C] PBR06, a carbon-11 labeled form of PBR06, was designed and synthesized for the first time. The standard PBR06 was synthesized from 2, 5-dimethoxybenzaldehyde in three steps with ...