A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate
X Zhu, KD Kreutter, H Hu, MR Player, MD Gaul
文献索引：Zhu, Xizhen; Kreutter, Kevin D.; Hu, Huaping; Player, Mark R.; Gaul, Micheal D. Tetrahedron Letters, 2008 , vol. 49, # 5 p. 832 - 834
A novel reagent combination, Tf2O/Na2CO3· 1.5 H2O2, has been developed for the oxidation of highly electron deficient pyridines to their corresponding N-oxides. The N- oxidation reaction, utilizing the in situ generated peracid, proceeds under mild conditions that allow for a number of functional groups and substitution patterns on the pyridine ring.
