Possible Antineoplastic Agents, Part XVII: Synthesis, Antitumor and Antiangiogenic Study of Few Bioisosteres of Thalidomide Metabolites

…, K Sarker, A Ghosh, S Mishra, A Saha…

文献索引：Sen; Sarker; Ghosh; Mishra; Saha; Goswami; Gupta; De Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1872 - 1878

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摘要

Abstract Two series of bioisostere of thalidomide metabolites and their cyclized variants were designed, synthesized and characterized. In vivo antitumor activity was studied on EAC in swiss albino mice. Cytotoxicity study was carried out on HUVEC and Vero cell lines by MTT assay method. Antiangiogenic activity on Ehrlich ascites tumor (EAT) was investigated studying inhibition of formation of micro vessels by identification of CD31 ...