Biosynthesis of the lincomycins. 1. Studies using stable isotopes on the biosynthesis of the propyl-and ethyl-L-hygric acid moieties of lincomycins A and B

NM Brahme, JE Gonzalez, JP Rolls…

文献索引：Brahme; Gonzalez; Rolls; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 25 p. 7873 - 7878

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被引用次数: 43

摘要

Abstract: The biosynthesis of the propyl-L-hygric acid and ethyl-L-hygric acid moieties of lincomycins A and B has been examined by using deuterated and carbon-13 labeled precursors in combination with carbon-13 NMR and mass spectral analysis. The results, using specifically deuterated tyrosine, DOPA, and methionine, demonstrate that tyrosine is converted via DOPA to an intermediate that undergoes aromatic ring cleavage most ...