Synthesis and separation of diastereomeric imino alcohol derivatives of chiral phthalides: a method for assignment of phthalide absolute configurations
WH Pirkle, TJ Sowin
文献索引：Pirkle, William H.; Sowin, Thomas J. Journal of Organic Chemistry, 1987 , vol. 52, # 14 p. 3011 - 3017
Representative members of a series of chiral type 1 phthalides were converted with Lawesson's reagent to the corresponding thionophthalides. On treatment with any of several configurationally known chiral amino alcohols in the presence of mercuric trifluoroacetate, diastereomeric imino alcohols are afforded. These prove to be readily separable by chromatography on either silica or chiral stationary phases derived from the N-3, 5- ...
