Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors
…, M Labarre, M Gosselin, D Bellemare…
文献索引：Page; Naismith; Schmidt; Coupal; Labarre; Gosselin; Bellemare; Payza; Brown Journal of Medicinal Chemistry, 2001 , vol. 44, # 15 p. 2387 - 2390
The design, synthesis and pharmacological evaluation of a novel class of Dmt-Tic dipeptide analogues are described. These resulting analogues bearing different C-terminal functionalities were found to bind to the human δ receptor with high affinity. One specific class of dipeptides bearing urea/thiourea functionalities showed partial to full activation of the δ receptor. Several dipeptides also showed good binding affinities with full activation ...
