Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. II. Mercaptosulfur Mustard and Its Esters1

HCF SU, C SEGEBARTH, KC TSOU

文献索引：Su,H.C.F. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 4990 - 4992

全文：HTML全文

被引用次数: 2

摘要

2-Chloro-2'-mercaptodiethyl sulfide (MSM)(I) was synthesized from ethanedithiol and vinyl chloride, and also from 1, 2, 3-0xadithiolane-% oxide (111) with concentrated hydrochloric acid or 2-chloroethyl mercaptan. Its esters were obtained from acylation of I with acid chlorides. 2-Chloro-2'-thioacetoxy diethyl sulfide was also prepared from chlorination of 2- hydroxy-2'-thioacetoxy diethyl sulfide which in turn was obtained from the reaction of 2- ...