New Journal of Chemistry

Preparation of benzylphosphonates via a palladium (0)-catalyzed cross-coupling of H-phosphonate diesters with benzyl halides. Synthetic and mechanistic studies

…, M Kalek, M Jezowska, J Stawinski

文献索引：Laven, Gaston; Kalek, Marcin; Jezowska, Martina; Stawinski, Jacek New Journal of Chemistry, 2010 , vol. 34, # 5 p. 967 - 975

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被引用次数: 18

摘要

We have developed a new, efficient method for the synthesis of benzylphosphonate and benzylphosphonothioate diesters via a palladium (0)-catalyzed cross-coupling reaction between benzyl halides and H-phosphonate or H-phosphonothioate diesters, using Pd2 (dba) 3 (CHCl3) as a palladium source and Xantphos as a supporting ligand. Some mechanistic aspects of these reactions were investigated using 31P NMR spectroscopy.