前往化源商城

Stem Cells Translational Medicine 2015-08-01

Postinfarction Functional Recovery Driven by a Three-Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.

Santiago Roura, Carolina Soler-Botija, Juli R Bagó, Aida Llucià-Valldeperas, Marco A Férnandez, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Jerónimo Blanco, Antoni Bayes-Genis

文献索引:Stem Cells Transl. Med. 4 , 956-66, (2015)

全文:HTML全文

摘要

Considerable research has been dedicated to restoring myocardial cell slippage and limiting ventricular remodeling after myocardial infarction (MI). We examined the ability of a three-dimensional (3D) engineered fibrin patch filled with human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) to induce recovery of cardiac function after MI. The UCBMSCs were modified to coexpress luciferase and fluorescent protein reporters, mixed with fibrin, and applied as an adhesive, viable construct (fibrin-cell patch) over the infarcted myocardium in mice (MI-UCBMSC group). The patch adhered well to the heart. Noninvasive bioluminescence imaging demonstrated early proliferation and differentiation of UCBMSCs within the construct in the postinfarct mice in the MI-UCBMSC group. The implanted cells also participated in the formation of new, functional microvasculature that connected the fibrin-cell patch to both the subjacent myocardial tissue and the host circulatory system. As revealed by echocardiography, the left ventricular ejection fraction and fractional shortening at sacrifice were improved in MI-UCBMSC mice and were markedly reduced in mice treated with fibrin alone and untreated postinfarction controls. In conclusion, a 3D engineered fibrin patch composed of UCBMSCs attenuated infarct-derived cardiac dysfunction when transplanted locally over a myocardial wound.©AlphaMed Press.

相关化合物

结构式 名称/CAS号 全部文献
乙醇 结构式 乙醇
CAS:64-17-5
异硫氰酸荧光素酯 结构式 异硫氰酸荧光素酯
CAS:3326-32-7
异硫氰酸荧光素 结构式 异硫氰酸荧光素
CAS:27072-45-3
异氟醚 结构式 异氟醚
CAS:26675-46-7
甲醛 结构式 甲醛
CAS:50-00-0
丙二醇 结构式 丙二醇
CAS:57-55-6
L-谷氨酰胺 结构式 L-谷氨酰胺
CAS:56-85-9
腔肠素 结构式 腔肠素
CAS:55779-48-1