A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor

M Montembault, G Vo-Thanh, A Deyine…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 6 p. 1543 - 1546

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被引用次数: 18

摘要

... Bioorganic & Medicinal Chemistry Letters. ... This study suggests that the discovery of ligands could be improved by the design of chemical functional groups (or probes) not rigidified to a central structure (or scaffold). ...