Journal of pharmaceutical sciences

Potential antineoplastic agents derived from 1, 2??epoxyindan

J Sam, TC Snapp

文献索引：Sam,J.; Snapp,T.C. Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 1364 - 1367

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被引用次数: 2

摘要

II For example, the reaction of 1.2-epoxyindan (I) with aziridine (111) afforded 1-aziridipyl-2-indanol (IV) which was readily converted to 1,4-bis(2-hy- droxy-1-indany1)piperazine (V). The latter also was prepared by the direct action of piperazine with 1.2-epoxyindan as deb 4 by Mousseron (6). The indanamines derived from 1,2- epoxyindan are listed in Table I. The nitrogen mustards (1711) were prepared by the chlorination of the corresponding alcohol (VI) Received ...