One-pot neat reactions of carboxylic esters and alkylenediamines for efficient preparation of N-acylalkylenediamines

WC Chou, CW Tan, SF Chen, H Ku

文献索引：Chou, Wen-Chih; Tan, Chang-Wei; Chen, Shyh-Fong; Ku, Hao Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10015 - 10017

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被引用次数: 38

摘要

The amide unit is one of the most widely occurring functional groups. It is present as a key feature in many important natural products and man-made compounds. 1 For example (Scheme 1), N-acylalkylenediamines2 are used to react with 4-amino-2-chloro-6, 7- dimethoxyquinazolines to give a variety of antihypertensive agents. 3 Though the direct conversion of esters to amides has been reported, the previous application of this method ...