Arylthioamides as H2S donors: l-cysteine-activated releasing properties and vascular effects in vitro and in vivo

…, I Pugliesi, E Barresi, G Nesi, S Rapposelli…

文献索引：Martelli, Alma; Testai, Lara; Citi, Valentina; Marino, Alice; Pugliesi, Isabella; Barresi, Elisabetta; Nesi, Giulia; Rapposelli, Simona; Taliani, Sabrina; Da Settimo, Federico; Breschi, Maria C.; Calderone, Vincenzo ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 904 - 908

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被引用次数: 25

摘要

A small library of arylthioamides 1–12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or in the presence of an organic thiol such as l-cysteine. A number of arylthioamides (1–3 and 7) showed a slow and l-cysteine-dependent H2S-releasing mechanism, similar to that exhibited by the reference slow H2S-releasing agents, such as diallyl disulfide (DADS) and the phosphinodithioate derivative GYY 4137. ...