Tetrahedron Letters

A facile procedure for O-tritylation

S Murata, R Noyori

文献索引：Murata, S.; Noyori, R. Tetrahedron Letters, 1981 , vol. 22, p. 2107 - 2108

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被引用次数: 31

摘要

Although trityl group is widely used for the protection of hydroxylic functions, there exist only a few methods for such operation. 2, 3 We report here a facile recipe which finds widespread application for the blocking of alcohols, phenols, carboxylic acids, etc. This procedure utilizes equimolar amounts of a trimethylsilylated hydroxyl compound (I) and trimethyltrityloxysilane(II) and 1 mol% of trimethylsilyl triflate (TMSOTf) as the catalyst. The ...