Although trityl group is widely used for the protection of hydroxylic functions, there exist only a few methods for such operation. 2, 3 We report here a facile recipe which finds widespread application for the blocking of alcohols, phenols, carboxylic acids, etc. This procedure utilizes equimolar amounts of a trimethylsilylated hydroxyl compound (I) and trimethyltrityloxysilane(II) and 1 mol% of trimethylsilyl triflate (TMSOTf) as the catalyst. The ...
