前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

6-Aryl-1, 4-dihydro-benzo [d][1, 3] oxazin-2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists

P Zhang, EA Terefenko, A Fensome…

文献索引：Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382

全文：HTML全文

被引用次数: 67

摘要

Novel 6-aryl-1, 4-dihydro-benzo [d][1, 3] oxazin-2-ones were synthesized and tested as progesterone receptor (PR) antagonists. These compounds were potent and showed good selectivity for PR over other steroid receptors such as the glucocorticoid and androgen receptors (eg, greater than 80-fold selectivity at PR for 4h). Numerous 6-aryl benzoxazinones (eg, 4h-j) were active orally in the uterine decidualization and component ...

间溴氟苯结构式

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

6-(3-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氟苯基)-4,4-二...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(3-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氟苯基)-4,4-二...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(3-甲氧基苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-甲氧基苯基)-4,4...

3-氯苯硼酸结构式

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~79%

6-(3-氯苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯苯基)-4,4-二...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(3-氯苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯苯基)-4,4-二...

4-溴-2-氯-1-氟苯结构式

4-溴-2-氯-1-氟苯

Boronic acid, (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)- (9CI)结构式

Boronic acid, (...

~%

6-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-4-氟苯基)-4...

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

6-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-4-氟苯基)-4...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(3-氯-4-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-4-氟苯基)-4...

4-溴-2-氟苯腈结构式

4-溴-2-氟苯腈

Boronic acid, (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)- (9CI)结构式

Boronic acid, (...

~%

5-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁英-6-基)-2-氟苯甲腈结构式

5-(4,4-二甲基-2-氧代...

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

5-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁英-6-基)-2-氟苯甲腈结构式

5-(4,4-二甲基-2-氧代...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

5-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁英-6-基)-2-氟苯甲腈结构式

5-(4,4-二甲基-2-氧代...

3-氯-5-氟苯腈结构式

3-氯-5-氟苯腈

Boronic acid, (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)- (9CI)结构式

Boronic acid, (...

~82%

3-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)-5-氟苯甲腈结构式

3-(4,4-二甲基-2-氧代...

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

3-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)-5-氟苯甲腈结构式

3-(4,4-二甲基-2-氧代...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

3-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)-5-氟苯甲腈结构式

3-(4,4-二甲基-2-氧代...

1-溴-3-氯-5-氟苯结构式

1-溴-3-氯-5-氟苯

Boronic acid, (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)- (9CI)结构式

Boronic acid, (...

~%

6-(3-氯-5-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-5-氟苯基)-4...

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

6-(3-氯-5-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-5-氟苯基)-4...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(3-氯-5-氟苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(3-氯-5-氟苯基)-4...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

Boronic acid, (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)- (9CI)结构式

Boronic acid, (...

6-溴-4,4-二甲基-1,4-二氢苯并噁唑-2-酮结构式

6-溴-4,4-二甲基-1,4...

~%

3-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)苯甲腈结构式

3-(4,4-二甲基-2-氧代...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

3-(4,4-二甲基-2-氧代-2,4-二氢-1H-苯并[d][1,3]噁嗪)苯甲腈结构式

3-(4,4-二甲基-2-氧代...

2-(2-AMINO-5-BROMOPHENYL)PROPAN-2-OL结构式

2-(2-AMINO-5-BR...

~%

6-(2-氯苯基)-4,4-二甲基-1H-苯并[d][1,3]噁嗪-2(4h)-酮结构式

6-(2-氯苯基)-4,4-二...