General preparative synthesis of 2′??O??methylpyrimidine ribonucleosides

…, RH Springer, G Vasquez, RS Andrews…

文献索引：Ross; Springer; Vasquez; Andrews; Cook; Acevedo Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 765 - 769

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被引用次数: 12

摘要

Abstract A convergent and general approach to synthesizing 2′-O-Methylpyrimidine ribonucleosides 4a-e, 6, 7 on a multigram scale is described which begins with an improved procedure for making larger quantities of 2-O-methyl-1, 3, 5-tri-O-benzoyl-α-D-ribose. The sugar was reacted with the desired silylated pyrimidines at room temperature under Vorbrüggen conditions. The crude products contained less than 10% of the α anomers ...