Journal of the American Chemical Society 2005-04-06

Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.

Christian Fischer, Gregory C Fu

文献索引：J. Am. Chem. Soc. 127 , 4594, (2005)

全文：HTML全文

摘要

A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.