Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine

R Yella, N Khatun, SK Rout, BK Patel

文献索引：Yella, Ramesh; Khatun, Nilufa; Rout, Saroj Kumar; Patel, Bhisma K. Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3235 - 3245

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被引用次数: 29

摘要

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1, 3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated ...