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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Antihypertensive 5, 6-diarylpyridazin-3-ones

R Buchman, JA Scozzie, ZS Ariyan…

文献索引：Buchman; Scozzie; Ariyan; Heilman; Rippin; Pyne; Powers; Matthews Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1398 - 1405

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被引用次数: 16

摘要

The synthesis of a series of 5, 6-diarylpyridazinones is described, Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid@ OCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5, 6-diphenyl rings, a 0- substituted alkyl group at the 2 position of the ring, and an acetyl or cyano substituent at ...

2-[2'-(isopropylideneamino)ethyl]-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one结构式

2-[2'-(isopropy...

~32%

4-acetyl-5,6-bis(4-chlorophenyl)-2-[2-(propan-2-ylamino)ethyl]pyridazin-3-one结构式

4-acetyl-5,6-bi...

4-acetyl-5,6-bis(4-chlorophenyl)-2-(2-aminoethyl)-2H-pyridazin-3-one结构式

4-acetyl-5,6-bi...

~%

4-acetyl-5,6-bis(4-chlorophenyl)-2-[2-(propan-2-ylamino)ethyl]pyridazin-3-one结构式

4-acetyl-5,6-bi...

碳酸乙烯酯结构式

碳酸乙烯酯

3,4-bis(4-fluorophenyl)-6-oxo-1H-pyridazine-5-carbonitrile结构式

3,4-bis(4-fluor...

~62%

4-Pyridazinecarbonitrile, 5,6-bis(4-fluorophenyl)-2,3-dihydro-2-(2-hydroxyethyl)-3-oxo-结构式

4-Pyridazinecar...

4-Acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one结构式

4-Acetyl-5,6-bi...

~52%

4-acetyl-5,6-bis(4-chlorophenyl)-2-(1-hydroxypropan-2-yl)pyridazin-3-one结构式

4-acetyl-5,6-bi...

(E)-1,2-bis(3,4-dichlorophenyl)-2-hydrazonoethan-1-one结构式

(E)-1,2-bis(3,4...

~37%

4-Pyridazinecarbonitrile, 5,6-bis(3,4-dichlorophenyl)-2,3-dihydro-3-ox o-结构式

4-Pyridazinecar...

(E)-1,2-bis(4-bromophenyl)-2-hydrazonoethan-1-one结构式

(E)-1,2-bis(4-b...

~47%

3,4-bis(4-bromophenyl)-6-oxo-1H-pyridazine-5-carbonitrile结构式

3,4-bis(4-bromo...

4-Acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one结构式

4-Acetyl-5,6-bi...

~%

4-acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one结构式

4-acetyl-2-(2-a...

2-(2-(5-acetyl-3,4-bis(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)isoindoline-1,3-dione结构式

2-(2-(5-acetyl-...

~29%

4-acetyl-2-(2-aminoethyl)-5,6-bis(4-chlorophenyl)pyridazin-3-one结构式

4-acetyl-2-(2-a...

苯偶酰腙结构式

乙酰乙酸乙酯结构式

乙酰乙酸乙酯

~%

5-acetyl-3,4-diphenyl-1H-pyridazin-6-one结构式

5-acetyl-3,4-di...

2,2'-dichloro-benzil-monohydrazone结构式

2,2'-dichloro-b...

~%

4-Pyridazinecarbonitrile, 5,6-bis(2-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

4-Pyridazinecarbonitrile, 5,6-bis(4-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

~20%

methyl 2-[3,4-bis(4-chlorophenyl)-5-cyano-6-oxopyridazin-1-yl]acetate结构式

methyl 2-[3,4-b...

(E)-4,4'-dichlorobenzil monohydrazone结构式

(E)-4,4'-dichlo...

~48%

4-Pyridazinecarbonitrile, 5,6-bis(4-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

ethyl 4-[3,4-bis(4-chlorophenyl)-5-cyano-6-oxopyridazin-1-yl]butanoate结构式

ethyl 4-[3,4-bi...

~29%

1(6H)-Pyridazinebutanoicacid, 3,4-bis(4-chlorophenyl)-5-cyano-6-oxo-结构式

1(6H)-Pyridazin...

4-Pyridazinecarbonitrile, 5,6-bis(4-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

~%

1(6H)-Pyridazinebutanoicacid, 3,4-bis(4-chlorophenyl)-5-cyano-6-oxo-结构式

1(6H)-Pyridazin...

碳酸乙烯酯结构式

碳酸乙烯酯

4-Pyridazinecarbonitrile, 5,6-bis(2-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

~80%

4-Pyridazinecarbonitrile,5,6-bis(2-chlorophenyl)-2,3-dihydro-2-(2-hydroxyethyl)-3-oxo-结构式

4-Pyridazinecar...

4-acetyl-5,6-bis(4-chlorophenyl)-2-(2-aminoethyl)-2H-pyridazin-3-one结构式

4-acetyl-5,6-bi...

~%

N-[2-[5-acetyl-3,4-bis(4-chlorophenyl)-6-oxo-pyridazin-1-yl]ethyl]acetamide结构式

N-[2-[5-acetyl-...

未登录结构式

~34%

4-acetyl-5,6-bis(4-fluorophenyl)-2H-pyridazin-3-one结构式

4-acetyl-5,6-bi...

碳酸乙烯酯结构式

碳酸乙烯酯

4-acetyl-5,6-bis(4-fluorophenyl)-2H-pyridazin-3-one结构式

4-acetyl-5,6-bi...

~45%

4-acetyl-5,6-bis(4-fluorophenyl)-2-(2-hydroxyethyl)pyridazin-3-one结构式

4-acetyl-5,6-bi...

对甲苯磺酸2-甲氧基乙酯结构式

对甲苯磺酸2-甲氧基乙酯

4-Acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one结构式

4-Acetyl-5,6-bi...

~26%

3(2H)-Pyridazinone,4-acetyl-5,6-bis(4-chlorophenyl)-2-(2-methoxyethyl)-结构式

3(2H)-Pyridazin...

碳酸乙烯酯结构式

碳酸乙烯酯

4-Pyridazinecarbonitrile, 5,6-bis(3,4-dichlorophenyl)-2,3-dihydro-3-ox o-结构式

4-Pyridazinecar...

~26%

5,6-Bis(3,4-dichlorophenyl)-2-(2-hydroxyethyl)-3-oxo-2,3-dihydro-4-pyridazinecarbonitrile结构式

5,6-Bis(3,4-dic...

ethyl 5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-3-oxo-2,3-dihydropyridazine-4-carboxylate结构式

ethyl 5,6-bis(4...

~81%

5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-3-oxo-pyridazine-4-carboxylic acid结构式

5,6-bis(4-chlor...

碳酸乙烯酯结构式

碳酸乙烯酯

4-Pyridazinecarbonitrile, 5,6-bis(4-chlorophenyl)-2,3-dihydro-3-oxo-结构式

4-Pyridazinecar...

~59%

4-Pyridazinecarbonitrile, 5,6-bis(4-chlorophenyl)-2,3-dihydro-2-(2-hydroxyethyl)-3-oxo-结构式

4-Pyridazinecar...

苯偶酰腙结构式

~31%

3(2H)-Pyridazinone,4-(4-methoxyphenyl)-5,6-diphenyl-结构式

3(2H)-Pyridazin...

未登录结构式

~%

5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-3-oxo-pyridazine-4-carboxylic acid结构式

5,6-bis(4-chlor...