Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta

…, RE Gerber, B Sloan, J Luo, R Cooper…

文献索引：Bierer, Donald E.; Dubenko, Larisa G.; Zhang, Pingsheng; Lu, Qing; Imbach, Patricia A.; Garofalo, Albert W.; Phuan, Puay-Wah; Fort, Diana M.; Litvak, Joane; Gerber, R. Eric; Sloan, Barbara; Luo, Jian; Cooper, Raymond; Reaven, Gerald M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2754 - 2764

全文：HTML全文

被引用次数: 90

摘要

Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was ...