Xitrogen analogs of ketenes have been used as reagents for the formation of the peptide bond. The N-protected amino acids glycine, alanine and methionine were converted in high yield to stable, crystalline adducts with the ketenimine I. The adducts were formed in non- polar, aqueous or alcoholic solutions. Reaction of an amino acid ester with an adduct afforded the peptides; alternately, the three starting materials could be placed in the ...
![Carbamic acid,[2-[(diphenylacetyl)(4-methylphenyl)amino]-2-oxoethyl]-, phenylmethyl ester(9CI)结构式](https://image.chemsrc.com/caspic/394/7465-75-0.png)
