Journal of medicinal chemistry

Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer

Q Hu, L Yin, RW Hartmann

文献索引：Yin, Lina; Lucas, Simon; Maurer, Frauke; Kazmaier, Uli; Hu, Qingzhong; Hartmann, Rolf W. Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6629 - 6633

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被引用次数: 30

摘要

Postmenopausal women are at high risk for cardiovascular diseases because of the estrogen deficiency. As for postmenopausal breast cancer patients, this risk is even higher due to inhibition of estrogens biosyntheses in peripheral tissue by the aromatase (CYP19) inhibitors applied. Because estrogen deficiency results in significantly elevated aldosterone levels, which are a major cause of cardiovascular diseases, dual inhibition of CYP19 and ...