Synthesis and Antibacterial Evaluation of a Novel Series of 2??(1, 2??Dihydro??3??oxo??3H??pyrazol??2??yl) benzothiazoles

…, S De Jonghe, B Vanderhoydonck…

文献索引：Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265

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被引用次数: 9

摘要

Abstract The 2-(1, 2-dihydro-3-oxo-3H-pyrazol-2-yl) benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focused library of benzothiazoles that was subjected to antibacterial screening. In a first round of screening, activity of the compounds against six ...