Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions

…, J Alcázar, A de la Hoz, Á Díaz-Ortiz, SAA de Diego

文献索引：Munoz, Juan De M.; Alcazar, Jesus; De La Hoz, Antonio; Diaz-Ortiz, Angel; Alonso De Diego, Sergio-A. Green Chemistry, 2012 , vol. 14, # 5 p. 1335 - 1341

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被引用次数: 19

摘要

A safe, green and functional-group-tolerant flow version of the direct amide bond formation mediated by Grignard reagents (the Bodroux reaction) is described. The procedure can be applied to a wide variety of primary and secondary amines and anilines, as well as to aromatic and aliphatic esters. The flow approach leads to improved yields and selectivities in the reaction, which has a sustainable purification procedure and a simple scale-up. This ...