A generalized synthesis of 3-amino-5-aryl-, 3-amino-5-polyfluorophenyl-, and 3-amino-5-alkyl-1, 2, 4-oxadiazoles through ring-degenerate rearrangements
Abstract-A generalized synthesis of 3-amino-5-aryl-, 3-amino-5-polyfluorophenyl-and 3- amino-5-alkyl-1, 2, 4-oxadiazoles has been developed starting from the 3-amino-5-methyl-1, 2, 4-oxadiazole as a common synthon. Aroylation or alkanoylation of this aminooxadiazole, followed by thermallyinduced ring-degenerate equilibration of resulting 3-acylamino compounds, and final acid hydrolysis of the 3-acetylamino-5-aryl-(or 5-polyfluorophenyl-), ...
