Design and synthesis of [(2, 3-dichlorophenyl) piperazin-1-yl] alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype

…, SM Husbands, A Kieltyka, R Brodbeck…

文献索引：Robarge; Husbands; Kieltyka; Brodbeck; Thurkauf; Newman Journal of Medicinal Chemistry, 2001 , vol. 44, # 19 p. 3175 - 3186

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被引用次数: 78

摘要

The dopamine D3 receptor subtype has been recently targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. However, definitive behavioral investigations have been hampered by the lack of highly selective D3 agonists and antagonists. In an attempt to design a novel class of D3 ligands with which to study this receptor system, a series of chemically divergent compounds that possessed ...