ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

…, S Dandapani, M Palmer, L Whitesell…

文献索引：Youngsaye, Willmen; Hartland, Cathy L.; Morgan, Barbara J.; Ting, Amal; Nag, Partha P.; Vincent, Benjamin; Mosher, Carrie A.; Bittker, Joshua A.; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L.; Munoz, Benito Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1501 - 1507

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被引用次数: 7

摘要

Abstract The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened> 300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for ...