Tetrahedron letters

PalladiumP (t-Bu) 3-catalyzed synthesis of aryl t-butyl ethers and application to the first synthesis of 4-chlorobenzofuran

M Watanabe, M Nishiyama, Y Koie

文献索引：Watanabe, Makoto; Nishiyama, Masakazu; Koie, Yasuyuki Tetrahedron Letters, 1999 , vol. 40, # 50 p. 8837 - 8840

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被引用次数: 66

摘要

Pd P (t-Bu) 3 catalyzed reaction of aryl halides with sodium t-butoxide effectively to give aryl t- butyl ethers. The high catalytic activity realized the formation of aryl t-butyl ethers from not only electron-deficient aryl halides but also electron-rich aryl halides. Moreover, the first synthesis of 4-chlorobenzofuran was attained utilizing the selective mono-t-butoxylation of aryl dihalide.