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A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on p K a and binding affinity and evidence for …

J Olsen, P Seiler, B Wagner, H Fischer…

文献索引:Organic and Biomolecular Chemistry, , vol. 2, # 9 p. 1339 - 1352

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被引用次数: 65

摘要

... The importance of organofluorine in medicinal chemistry has been increasing ever since the ... 2 In contrast, modulation of the physico-chemical properties (such as lipophilicity, metabolic ... it has become clear from crystallographic and computational studies that organic C–F is a ...